Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.44 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.44 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23547183 | 1.00 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2HTTITGA5 | |
| SCHEMBL21821307 | 0.91 | SMN1; SMN2 (0.48) | NPC1RAB9ASMN1; SMN2HTTITGA5 | |
| SCHEMBL21821305 | 0.91 | SMN1; SMN2 (0.48) | NPC1RAB9ASMN1; SMN2HTTITGA5 | |
| SCHEMBL19283658 | 0.89 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2HTTITGA5 | |
| SCHEMBL21821310 | 0.87 | ITGA5 (0.45) | NPC1RAB9ASMN1; SMN2HTTITGA5 | |
| SCHEMBL19283490 | 0.87 | ITGA5 (0.45) | NPC1RAB9ASMN1; SMN2HTTITGA5 | |
| SCHEMBL19283637 | 0.86 | ITGA5 (0.47) | NPC1RAB9ASMN1; SMN2HTTITGA5 | |
| SCHEMBL30645019 | 0.86 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2HTTITGA5 | |
| SCHEMBL20743761 | 0.86 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2HTTITGA5 | |
| SCHEMBL21821324 | 0.86 | ITGA5 (0.45) | NPC1RAB9ASMN1; SMN2HTTITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109153667-B | Novel potassium channel inhibitors | 阿塞西翁制药公司 | 2021-04-02 | — | — | CN | claimed |
| EP-3419973-B1 | NOVEL POTASSIUM CHANNEL INHIBITORS | ACESION PHARMA APS (DK) | 2020-04-08 | — | — | EP | claimed |
| CN-109153667-B | Novel potassium channel inhibitors | 阿塞西翁制药公司 | 2021-04-02 | — | — | CN | disclosed |