Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 15/20 | 0.44 |
| ▸ | F2 | P00734 | 4/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21822846 | 1.00 | PLA2G10 (0.45) | PLA2G10F10F2DPP4DPP8 | |
| SCHEMBL21822172 | 0.90 | F10 (0.57) | PLA2G10F10F2PRSS1 | |
| SCHEMBL25016310 | 0.90 | F10 (0.57) | PLA2G10F10F2PRSS1 | |
| SCHEMBL28585854 | 0.89 | PLA2G10 (0.42) | PLA2G10F10F2DPP4DPP8 | |
| SCHEMBL28579790 | 0.84 | PLA2G10 (0.45) | PLA2G10F10F2KDM1A | |
| SCHEMBL25017885 | 0.80 | F10 (0.49) | F10F2PRSS1 | |
| SCHEMBL25016830 | 0.77 | F10 (0.53) | PLA2G10F10F2 | |
| SCHEMBL25015875 | 0.76 | F10 (0.43) | F10F2PRSS1 | |
| SCHEMBL25016835 | 0.74 | ST14 (0.44) | F10F2 | |
| SCHEMBL25015740 | 0.74 | F10 (0.50) | F10F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3860636-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | Disc Medicine, Inc. (US) | 2021-08-11 | — | — | EP | disclosed |
| CN-112996529-A | Matriptase 2 inhibitor and application thereof | 迪斯克医药公司 | 2021-06-18 | — | — | CN | disclosed |
| WO-2020072580-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. (US) | 2020-04-09 | — | — | WO | disclosed |