Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR9 | P51686 | 2/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 6/20 | 0.44 |
| ▸ | F10 | P00742 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30180535 | 0.90 | CCR9 (0.54) | CCR9CNR1F10DRD4PPARG | |
| SCHEMBL28582822 | 0.90 | CCR9 (0.54) | CCR9CNR1F10DRD4PPARG | |
| SCHEMBL28582824 | 0.90 | CCR9 (0.54) | CCR9CNR1F10DRD4PPARG | |
| SCHEMBL30180858 | 0.89 | CCR9 (0.47) | CCR9USP30CNR1F10DRD4 | |
| SCHEMBL28915544 | 0.86 | CCR9 (0.47) | CCR9CNR1F10DRD4SLC6A5 | |
| SCHEMBL21822127 | 0.84 | CCR9 (0.54) | CCR9CNR1F10DRD4PPARG | |
| SCHEMBL21822494 | 0.84 | CCR9 (0.49) | CCR9CNR1F10DRD4SLC6A5 | |
| SCHEMBL28582741 | 0.84 | CCR9 (0.53) | CCR9CNR1F10DRD4PPARG | |
| SCHEMBL28582742 | 0.84 | CCR9 (0.53) | CCR9CNR1F10DRD4PPARG | |
| SCHEMBL28572173 | 0.83 | USP30 (0.49) | USP30F10DRD4GPR119TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3860636-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | Disc Medicine, Inc. (US) | 2021-08-11 | — | — | EP | disclosed |
| CN-112996529-A | Matriptase 2 inhibitor and application thereof | 迪斯克医药公司 | 2021-06-18 | — | — | CN | disclosed |
| WO-2020072580-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. (US) | 2020-04-09 | — | — | WO | disclosed |