Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.41 |
| ▸ | UGT8 | Q16880 | 18/20 | 0.39 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.35 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.35 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.35 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30845006 | 0.91 | UGT8 (0.39) | P2RX3P2RX2UGT8 | |
| SCHEMBL21813842 | 0.90 | UGT8 (0.40) | UGT8 | |
| SCHEMBL21862150 | 0.88 | UGT8 (0.46) | UGT8EEDRBBP4SUZ12EZH2 | |
| SCHEMBL30845059 | 0.88 | UGT8 (0.46) | UGT8EEDRBBP4SUZ12EZH2 | |
| SCHEMBL30845106 | 0.88 | UGT8 (0.42) | UGT8 | |
| SCHEMBL21813574 | 0.88 | UGT8 (0.42) | UGT8 | |
| SCHEMBL21813577 | 0.88 | UGT8 (0.42) | UGT8 | |
| SCHEMBL21813606 | 0.87 | UGT8 (0.42) | UGT8 | |
| SCHEMBL30845110 | 0.86 | UGT8 (0.48) | UGT8EEDRBBP4SUZ12EZH2 | |
| SCHEMBL21828475 | 0.83 | UGT8 (0.48) | P2RX3P2RX2UGT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113423711-B | Thieno [3,2-B ] pyridine derivatives as UDP glycosyltransferase inhibitors and methods of use thereof | 建新公司 | 2024-03-15 | — | — | CN | claimed |
| CN-113423711-B | Thieno [3,2-B ] pyridine derivatives as UDP glycosyltransferase inhibitors and methods of use thereof | 建新公司 | 2024-03-15 | — | — | CN | disclosed |
| EP-3861000-A1 | THIENO[3,2-B]PYRIDINE DERIVATIVES AS UDP GLYCOSYLTRANSFERASE INHIBITORS AND METHODS OF USE | Genzyme Corporation (US) | 2021-08-11 | — | — | EP | disclosed |
| WO-2020072504-A1 | THIENO[3,2-B]PYRIDINE DERIVATIVES AS UDP GLYCOSYLTRANSFERASE INHIBITORS AND METHODS OF USE | GENZYME CORPORATION (US) | 2020-04-09 | — | — | WO | disclosed |