Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 13/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23406694 | 0.91 | EGFR (0.61) | EGFRERBB2LCKAURKARPS6KB1 | |
| SCHEMBL21835336 | 0.88 | ERBB2 (0.61) | EGFRERBB2LCKAURKARPS6KB1 | |
| SCHEMBL23406628 | 0.88 | ERBB2 (0.61) | EGFRERBB2LCKAURKARPS6KB1 | |
| SCHEMBL28710070 | 0.86 | EGFR (0.58) | EGFRERBB2LCKAURKARPS6KB1 | |
| SCHEMBL21835418 | 0.86 | EGFR (0.57) | EGFRERBB2LCKAURKARPS6KB1 | |
| SCHEMBL4868102 | 0.85 | ERBB2 (0.59) | EGFRERBB2LCKAURKARPS6KB1 | |
| SCHEMBL23406693 | 0.84 | EGFR (0.53) | EGFRERBB2LCKAURKARPS6KB1 | |
| SCHEMBL21835310 | 0.83 | EPHA2 (0.65) | EGFRERBB2LCK | |
| SCHEMBL21835274 | 0.83 | EGFR (0.73) | EGFRERBB2LCKAURKARPS6KB1 | |
| SCHEMBL21835414 | 0.83 | EGFR (0.62) | EGFRERBB2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3856726-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITOR, COMPOSITIONS, METHODS OF MAKING THEM AND THEIR USE | Black Diamond Therapeutics, Inc. (US) | 2021-08-04 | — | — | EP | disclosed |
| WO-2020068867-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITOR, COMPOSITIONS, METHODS OF MAKING THEM AND THEIR USE | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2020-04-02 | — | — | WO | disclosed |