Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.80 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.80 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.49 |
| ▸ | KDM4A | O75164 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20524109 | 0.89 | HDAC6 (1.00) | HDAC6HDAC1KDM4CKDM4AHDAC8 | |
| SCHEMBL20524116 | 0.87 | HDAC6 (0.73) | HDAC6HDAC1KDM4CKDM4AHDAC8 | |
| SCHEMBL20524102 | 0.74 | HDAC6 (1.00) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL27750482 | 0.74 | HDAC1 (0.56) | HDAC6HDAC1KDM4CKDM4AHDAC8 | |
| SCHEMBL21840273 | 0.72 | HDAC6 (0.71) | HDAC6HDAC1KMT2AKDM4EMEN1 | |
| SCHEMBL18688206 | 0.71 | HDAC1 (0.52) | HDAC6HDAC1KDM4CKDM4AHDAC8 | |
| SCHEMBL1576678 | 0.71 | HDAC1 (0.58) | HDAC6HDAC1KDM4CKDM4AHDAC8 | |
| SCHEMBL18688725 | 0.70 | HDAC6 (0.54) | HDAC6HDAC1KDM4CKDM4AHDAC8 | |
| SCHEMBL18688691 | 0.69 | HDAC6 (0.53) | HDAC6HDAC1KDM4CKDM4AHDAC8 | |
| SCHEMBL18688204 | 0.69 | HDAC6 (0.53) | HDAC6HDAC1KDM4CKDM4AHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200115350-A1 | Isoxazole Hydroxamic Acids As Histone Deacetylase 6 Inhibitors | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION | 2020-04-16 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115350-A1 | Isoxazole Hydroxamic Acids As Histone Deacetylase 6 Inhibitors | HDAC1, HDAC7, HDAC5 | HDAC6 10/4885HDAC1 1/4885KDM4C 175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.