Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pioglitazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 14/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | RXRA | P19793 | 1/20 | 1.00 |
| ▸ | MPC2 | O95563 | 1/20 | 0.66 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.53 |
| ▸ | PPARA | Q07869 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pioglitazone SCHEMBL1162192 | 1.00 | PPARG (1.00) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| Pioglitazone SCHEMBL29759383 | 1.00 | PPARG (1.00) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| Pioglitazone SCHEMBL29591932 | 1.00 | PPARG (1.00) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| Pioglitazone SCHEMBL3689044 | 1.00 | PPARG (1.00) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| Pioglitazone SCHEMBL611563 | 1.00 | PPARG (1.00) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| Pioglitazone SCHEMBL676871 | 1.00 | PPARG (1.00) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| Pioglitazone SCHEMBL1489588 | 1.00 | PPARG (1.00) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| Pioglitazone SCHEMBL4426214 | 0.99 | PPARG (0.98) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| Pioglitazone SCHEMBL4121 | 0.99 | PPARG (1.00) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| Pioglitazone SCHEMBL1162440 | 0.99 | PPARG (1.00) | PPARGCYP3A4RXRAMPC2CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 10761 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4734978-A2 | COMBINATION THERAPIES USING PSILOCYBIN | University of Padova (IT) | 2026-05-06 | — | — | EP | claimed |
| EP-3787631-B1 | MODULATORS OF ORPHAN NUCLEAR RECEPTORS FOR NASH AND OTHER METABOLIC DISORDERS | UNIV EMORY (US) | 2025-09-10 | — | — | EP | claimed |
| CN-120058978-A | Preparation method of Yang Shusang Huang Junyi polysaccharide with antidiabetic effect | 吉林化工学院 | 2025-05-30 | — | — | CN | claimed |
| US-20250170082-A1 | HPDL INHIBITORS AND USES THEREOF | NEW YORK UNIVERSITY (US) | 2025-05-29 | — | — | US | claimed |
| US-20250170113-A1 | METHOD OF INCREASING LIFESPAN IN MAMMALS | CELLULAR LONGEVITY, INC. | 2025-05-29 | — | — | US | claimed |
| CN-116410201-B | Flavonoid compound extracted from black mulberry plants and preparation method and application thereof | 上海医药工业研究院有限公司 | 2025-05-09 | — | — | CN | claimed |
| CN-119162095-B | Umbilical mesenchymal stem cell exosome and preparation method and application thereof | 广东壹加再生医学研究院有限公司 | 2025-03-21 | — | — | CN | claimed |
| US-20250092360-A1 | METHODS AND COMPOSITIONS FOR GENERATING SOMATOSTATIN+ INTERNEURONS FROM HUMAN FOREBRAIN NEURAL PROGENITOR CELLS | TRAILHEAD BIOSYSTEMS INC. | 2025-03-20 | — | — | US | claimed |
| CN-119574201-A | Sampling device for pioglitazone hydrochloride and application method thereof | 北京太洋药业股份有限公司 | 2025-03-07 | — | — | CN | claimed |
| CN-119455243-A | Pioglitazone hydrochloride microneedle drug delivery system for treating type II diabetes and preparation method thereof | 杭州医学院 | 2025-02-18 | — | — | CN | claimed |
| WO-2000006126-A1 | RAPIDLY DISINTEGRABLE SOLID PREPARATION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-10 | — | — | WO | claimed |
| WO-2000000195-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DIABETES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-01-06 | — | — | WO | claimed |
| WO-1999062047-A1 | PUBLICITY MEDIUM FOR MICROPHONES | PIVOT PUBLICIDAD, S.A. (ES) | 1999-12-02 | — | — | WO | claimed |
| WO-1997010705-A1 | WASHBASIN-TOILET-RESIDENCE FOR ANIMALS | CASTELLS TARAFA JOSE (ES) | 1997-03-27 | — | — | WO | claimed |
| US-5356913-A | Use of insulin sensitizing agents to treat hypertension | THE UPJOHN COMPANY (US) | 1994-10-18 | — | — | US | claimed |
| EP-0601001-A1 | PHARMACEUTICAL COMPOSITION CONTAINING 3-GUANIDINOPROPIONIC ACID AND PIOGLITAZONE GLIBENCLAMIDE OR GLIMEPIRIDE. | UPJOHN CO (US) | 1994-06-15 | — | — | EP | claimed |
| EP-0514452-B1 | USE OF INSULIN SENSITIZING AGENTS TO TREAT HYPERTENSION | THE UPJOHN COMPANY (US) | 1993-08-18 | — | — | EP | claimed |
| WO-1993003724-A1 | PHARMACEUTICAL COMPOSITION CONTAINING 3-GUANIDINOPROPIONIC ACID AND PIOGLITAZONE GLIBENCLAMIDE OR GLIMEPIRIDE | THE UPJOHN COMPANY (US) | 1993-03-04 | — | — | WO | claimed |
| EP-0514452-A1 | USE OF INSULIN SENSITIZING AGENTS TO TREAT HYPERTENSION. | UPJOHN CO (US) | 1992-11-25 | — | — | EP | claimed |
| WO-1991012003-A1 | USE OF INSULIN SENSITIZING AGENTS TO TREAT HYPERTENSION | THE UPJOHN COMPANY (US) | 1991-08-22 | — | — | WO | claimed |