Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.66 |
| ▸ | KDR | P35968 | 8/20 | 0.66 |
| ▸ | KIF5B | P33176 | 1/20 | 0.63 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.63 |
| ▸ | ABL1 | P00519 | 8/20 | 0.59 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21843573 | 0.94 | RET (0.69) | RETFGFR1KDRKIF5BCCDC6 | |
| SCHEMBL21843583 | 0.93 | RET (0.68) | RETFGFR1KDRKIF5BCCDC6 | |
| SCHEMBL21843513 | 0.93 | RET (0.68) | RETFGFR1KDRKIF5BCCDC6 | |
| SCHEMBL24283331 | 0.92 | RET (0.68) | RETFGFR1KDRKIF5BCCDC6 | |
| SCHEMBL24283201 | 0.92 | RET (0.67) | RETFGFR1KDRKIF5BCCDC6 | |
| SCHEMBL21843582 | 0.91 | FGFR1 (0.74) | RETFGFR1KDRKIF5BCCDC6 | |
| SCHEMBL24283346 | 0.91 | RET (0.66) | RETFGFR1KDRKIF5BCCDC6 | |
| SCHEMBL21843664 | 0.91 | RET (0.66) | RETFGFR1KDRKIF5BCCDC6 | |
| SCHEMBL24283334 | 0.91 | RET (0.69) | RETFGFR1KDRKIF5BCCDC6 | |
| SCHEMBL24283234 | 0.90 | RET (0.65) | RETFGFR1KDRKIF5BCCDC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020053812-A1 | ALKYNYL NICOTINAMIDE COMPOUNDS AS KINASE INHIBITORS | PURDUE RESEARCH FOUNDATION (US) | 2020-03-19 | — | — | WO | disclosed |