Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.78 |
| ▸ | LMNA | P02545 | 3/20 | 0.78 |
| ▸ | GAA | P10253 | 2/20 | 0.78 |
| ▸ | HTT | P42858 | 2/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.78 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.42 |
| ▸ | CCR4 | P51679 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23678506 | 0.89 | MAPT (0.80) | MAPTLMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL12240584 | 0.89 | MAPT (0.80) | MAPTLMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL16975619 | 0.89 | MAPT (0.80) | MAPTLMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL23354985 | 0.89 | MAPT (0.61) | MAPTLMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL19730460 | 0.89 | MAPT (0.80) | MAPTLMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL23355483 | 0.89 | MAPT (0.80) | MAPTLMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL2543291 | 0.88 | MAPT (1.00) | MAPTLMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL20639645 | 0.88 | MAPT (0.78) | MAPTLMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL3111183 | 0.88 | MAPT (1.00) | MAPTLMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL3107523 | 0.88 | MAPT (1.00) | MAPTLMNAGAAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3626242-A1 | ITRACONAZOLE ANALOGS AS INHIBITORS OF FIBROSIS | The Scripps Research Institute (US) | 2020-03-25 | — | — | EP | disclosed |