Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 16/20 | 0.52 |
| ▸ | IKZF3 | Q9UKT9 | 12/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | TNF | P01375 | 4/20 | 0.48 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | IL1B | P01584 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21848734 | 0.90 | CRBN (0.64) | CRBNIKZF3DDB1TNFIKZF1 | |
| SCHEMBL21848733 | 0.90 | CRBN (0.64) | CRBNIKZF3DDB1ADRA1DADRA1A | |
| SCHEMBL21848719 | 0.89 | CRBN (0.61) | CRBNIKZF3DDB1TNFIKZF1 | |
| SCHEMBL21848741 | 0.88 | CRBN (0.52) | CRBNIKZF3DDB1ADRA1DADRA1A | |
| SCHEMBL21834938 | 0.87 | CRBN (0.65) | CRBNIKZF3DDB1TNFIKZF1 | |
| SCHEMBL21848748 | 0.87 | CRBN (0.54) | CRBNIKZF3DDB1TNFIKZF1 | |
| SCHEMBL23739895 | 0.87 | CRBN (0.51) | CRBNIKZF3DDB1TNFIKZF1 | |
| SCHEMBL21848645 | 0.86 | CRBN (0.56) | CRBNIKZF3DDB1ADRA1DADRA1A | |
| SCHEMBL21848618 | 0.86 | CRBN (0.46) | CRBNIKZF3DDB1ADRA1DADRA1A | |
| SCHEMBL21848632 | 0.86 | CRBN (0.54) | CRBNIKZF3DDB1ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |
| WO-2020064002-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | 中国科学院上海药物研究所 | 2020-04-02 | — | — | WO | disclosed |