Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 6/20 | 0.42 |
| ▸ | PRKDC | P78527 | 3/20 | 0.42 |
| ▸ | MTOR | P42345 | 5/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.36 |
| ▸ | ATR | Q13535 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | MELK | Q14680 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | CLK3 | P49761 | 1/20 | 0.32 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21851207 | 0.91 | ATM (0.47) | ATMPRKDCMTORPIK3CAATR | |
| SCHEMBL21851136 | 0.88 | PRKDC (0.44) | ATMPRKDCMTORPIK3CAATR | |
| SCHEMBL21851073 | 0.88 | ATM (0.44) | ATMPRKDCMTORPIK3CAATR | |
| SCHEMBL21851077 | 0.85 | PRKDC (0.42) | ATMPRKDCMELK | |
| SCHEMBL23615865 | 0.85 | ATM (0.44) | ATMPRKDCMTORPIK3CAATR | |
| SCHEMBL21851038 | 0.84 | MCL1 (0.41) | ATMPRKDCMTORPIK3CAOPRD1 | |
| SCHEMBL21851039 | 0.84 | ATM (0.52) | ATMPRKDCMTORPIK3CAATR | |
| SCHEMBL21851019 | 0.84 | ATM (0.45) | ATMPRKDCMTORATRDYRK1A | |
| SCHEMBL21851056 | 0.83 | ATM (0.46) | ATMPRKDCMTORPIK3CAATR | |
| SCHEMBL21851161 | 0.82 | ATM (0.46) | ATMPRKDCMTORATRDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3845532-B1 | QUINOLINO-PYRROLIDIN-2-ONE DERIVATIVE AND APPLICATION THEREOF | MEDSHINE DISCOVERY INC (CN) | 2022-12-21 | — | — | EP | disclosed |
| US-11230549-B2 | Quinolino-pyrrolidin-2-one derivative and application thereof | MEDSHINE DISCOVERY INC. (CN) | 2022-01-25 | — | — | US | disclosed |
| US-20210380599-A1 | QUINOLINO-PYRROLIDIN-2-ONE DERIVATIVE AND APPLICATION THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2021-12-09 | — | — | US | disclosed |
| EP-3845532-A1 | QUINOLINO-PYRROLIDIN-2-ONE DERIVATIVE AND APPLICATION THEREOF | Medshine Discovery Inc. (CN) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020063855-A1 | QUINOLINO-PYRROLIDIN-2-ONE DERIVATIVE AND APPLICATION THEREOF | 南京明德新药研发有限公司 | 2020-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11230549-B2 | Quinolino-pyrrolidin-2-one derivative and application thereof | ATM, CHEK2, CHEK1 | ATM 1/4885PRKDC 227/4885MTOR 274/4885 |
| US-20210380599-A1 | QUINOLINO-PYRROLIDIN-2-ONE DERIVATIVE AND APPLICATION THEREOF | ATM, CHEK2, CHEK1 | ATM 1/4885PRKDC 227/4885MTOR 274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.