SCHEMBL2185243

SCHEMBL2185243

COC(=O)CN1CCc2nc(C(=O)NC3CCCC[C@@H]3NC(=O)c3cc4cc(Cl)ccc4[nH]3)sc2C1

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.78
F2 P00734 4/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4088000 1.00 F10 (0.78) F10F2
SCHEMBL4088001 1.00 F10 (0.78) F10F2
Hydrochloric Acid SCHEMBL1504025 0.99 F10 (0.77) F10F2
Hydrochloric Acid SCHEMBL1504028 0.99 F10 (0.77) F10F2
SCHEMBL10279897 0.92 F10 (0.66) F10F2
SCHEMBL4089870 0.91 F10 (0.72) F10F2
SCHEMBL763945 0.91 F10 (0.72) F10F2
SCHEMBL763914 0.91 F10 (0.79) F10F2
Hydrochloric Acid SCHEMBL2940624 0.91 F10 (0.76) F10F2
Hydrochloric Acid SCHEMBL2940627 0.91 F10 (0.76) F10F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2343290-A1 Diamine derivatives as factor X inhibitors Daiichi Sankyo Company, Limited (JP) 2011-07-13 EP disclosed