Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 19/20 | 0.72 |
| ▸ | LCK | P06239 | 18/20 | 0.72 |
| ▸ | EGFR | P00533 | 11/20 | 0.72 |
| ▸ | BTK | Q06187 | 4/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31039896 | 1.00 | JAK3 (0.72) | JAK3LCKEGFRBTK | |
| SCHEMBL21946913 | 1.00 | JAK3 (0.72) | JAK3LCKEGFRBTK | |
| SCHEMBL21946912 | 1.00 | JAK3 (0.72) | JAK3LCKEGFRBTK | |
| SCHEMBL21946804 | 0.96 | JAK3 (0.71) | JAK3LCKEGFRBTK | |
| SCHEMBL31039891 | 0.96 | JAK3 (0.71) | JAK3LCKEGFRBTK | |
| SCHEMBL21855217 | 0.96 | JAK3 (0.71) | JAK3LCKEGFRBTK | |
| SCHEMBL23459572 | 0.96 | JAK3 (0.76) | JAK3LCKEGFRBTK | |
| SCHEMBL21855158 | 0.96 | JAK3 (0.76) | JAK3LCKEGFRBTK | |
| SCHEMBL21855246 | 0.95 | JAK3 (0.74) | JAK3LCKEGFRBTK | |
| SCHEMBL21855161 | 0.91 | JAK3 (0.74) | JAK3LCKEGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081450-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |