Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 18/20 | 1.00 |
| ▸ | PFKFB1 | P16118 | 16/20 | 0.76 |
| ▸ | PFKFB2 | O60825 | 14/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21856933 | 0.86 | PFKFB3 (1.00) | PFKFB3PFKFB1PFKFB2 | |
| SCHEMBL21856723 | 0.86 | PFKFB3 (1.00) | PFKFB3PFKFB1PFKFB2 | |
| SCHEMBL28652895 | 0.84 | PFKFB3 (0.78) | PFKFB3PFKFB1PFKFB2 | |
| SCHEMBL30268345 | 0.84 | PFKFB3 (0.78) | PFKFB3PFKFB1PFKFB2 | |
| SCHEMBL21856728 | 0.73 | PFKFB3 (1.00) | PFKFB3PFKFB1PFKFB2 | |
| SCHEMBL21856810 | 0.72 | PFKFB3 (1.00) | PFKFB3PFKFB1PFKFB2 | |
| SCHEMBL21856796 | 0.72 | PFKFB3 (1.00) | PFKFB3PFKFB1PFKFB2 | |
| SCHEMBL21856838 | 0.71 | PFKFB3 (1.00) | PFKFB3PFKFB1PFKFB2 | |
| SCHEMBL21857036 | 0.70 | PFKFB3 (1.00) | PFKFB3PFKFB1PFKFB2ALDH1A1 | |
| SCHEMBL21856792 | 0.68 | PFKFB3 (1.00) | PFKFB3PFKFB1PFKFB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020080979-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO DISCOVERY LIMITED LIABILITY COMPANY (RU) | 2020-04-23 | — | — | WO | claimed |
| CN-113396145-A | PFKFB3 inhibitors and uses thereof | 盖罗发现有限责任公司 | 2021-09-14 | — | — | CN | disclosed |
| WO-2020080979-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO DISCOVERY LIMITED LIABILITY COMPANY (RU) | 2020-04-23 | — | — | WO | disclosed |