Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 14/20 | 0.64 |
| ▸ | CCNC | P24863 | 4/20 | 0.41 |
| ▸ | CDK8 | P49336 | 4/20 | 0.41 |
| ▸ | SPR | P35270 | 1/20 | 0.41 |
| ▸ | COMT | P21964 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21859057 | 0.88 | CHRM1 (0.70) | CHRM1CCNCCDK8 | |
| SCHEMBL21858935 | 0.86 | CHRM1 (0.68) | CHRM1CCNCCDK8 | |
| SCHEMBL21858992 | 0.82 | CHRM1 (0.53) | CHRM1SPR | |
| SCHEMBL22322792 | 0.82 | CHRM1 (0.48) | CHRM1SPR | |
| SCHEMBL21938242 | 0.81 | CHRM1 (0.75) | CHRM1CCNCCDK8 | |
| SCHEMBL21859069 | 0.81 | CHRM1 (0.65) | CHRM1CCNCCDK8 | |
| SCHEMBL21938332 | 0.80 | CHRM1 (0.61) | CHRM1SPR | |
| SCHEMBL20917729 | 0.79 | CHRM1 (0.44) | CHRM1CCNCCDK8 | |
| SCHEMBL21859068 | 0.79 | CHRM1 (0.65) | CHRM1CCNCCDK8 | |
| SCHEMBL21859103 | 0.78 | CHRM1 (1.00) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3867254-B1 | PYRROLO-PYRIDAZINE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | SUVEN LIFE SCIENCES LTD (IN) | 2023-05-31 | — | — | EP | disclosed |
| CN-113166160-A | Pyrrolopyridazine derivatives as positive allosteric modulators of muscarinic M1 receptors | 苏文生命科学有限公司 | 2021-07-23 | — | — | CN | disclosed |
| WO-2020079606-A9 | PYRROLO-PYRIDAZINE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | SUVEN LIFE SCIENCES LIMITED (IN) | 2020-08-13 | — | — | WO | disclosed |
| WO-2020079606-A1 | PYRROLO-PYRIDAZINE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | SUVEN LIFE SCIENCES LIMITED (IN) | 2020-04-23 | — | — | WO | disclosed |
| WO-2020079606-A1 | PYRROLO-PYRIDAZINE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | SUVEN LIFE SCIENCES LIMITED (IN) | 2020-04-23 | — | — | WO | disclosed |