Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.83 |
| ▸ | ABL1 | P00519 | 15/20 | 0.66 |
| ▸ | KIT | P10721 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29466397 | 1.00 | MAP4K1 (0.83) | MAP4K1ABL1KITPDGFRA | |
| SCHEMBL21859616 | 0.91 | MAP4K1 (0.78) | MAP4K1ABL1KITPDGFRA | |
| SCHEMBL29466390 | 0.91 | MAP4K1 (0.78) | MAP4K1ABL1KITPDGFRA | |
| SCHEMBL29466369 | 0.91 | MAP4K1 (1.00) | MAP4K1ABL1KITPDGFRA | |
| SCHEMBL21859612 | 0.91 | MAP4K1 (1.00) | MAP4K1ABL1KITPDGFRA | |
| SCHEMBL21859617 | 0.85 | MAP4K1 (1.00) | MAP4K1ABL1KITPDGFRA | |
| SCHEMBL22886309 | 0.83 | MAP4K1 (0.67) | MAP4K1ABL1KITPDGFRA | |
| SCHEMBL22886332 | 0.82 | MAP4K1 (0.72) | MAP4K1ABL1 | |
| SCHEMBL22885073 | 0.82 | MAP4K1 (0.83) | MAP4K1ABL1KITPDGFRA | |
| SCHEMBL22885050 | 0.81 | MAP4K1 (0.73) | MAP4K1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020069402-A1 | CINNOLINE COMPOUNDS AND FOR THE TREATMENT OF HPK1-DEPENDENT DISORDERS SUCH AS CANCER | GENENTECH, INC. (US) | 2020-04-02 | — | — | WO | disclosed |