SCHEMBL21862418

SCHEMBL21862418

CNC(=O)c1csc2c(C(F)(F)F)cc(O[C@H]3CCN(C(=O)OC(C)(C)C)C3)nc12

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ UGT8 Q16880 19/20 0.58
▸ PIK3CD O00329 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30845053 1.00 UGT8 (0.58) UGT8PIK3CD
SCHEMBL21862615 1.00 UGT8 (0.58) UGT8PIK3CD
SCHEMBL30844990 1.00 UGT8 (0.58) UGT8PIK3CD
SCHEMBL30844961 1.00 UGT8 (0.58) UGT8PIK3CD
SCHEMBL30845261 0.95 UGT8 (0.56) UGT8
SCHEMBL30844934 0.93 UGT8 (0.57) UGT8
SCHEMBL21813550 0.90 UGT8 (0.59) UGT8
SCHEMBL21813489 0.90 UGT8 (0.59) UGT8
SCHEMBL21813552 0.90 UGT8 (0.59) UGT8
SCHEMBL30845024 0.90 UGT8 (0.51) UGT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200102324-A1 UDP GLYCOSYLTRANSFERASE INHIBITORS AND METHODS OF USE GENZYME CORPORATION 2020-04-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200102324-A1 UDP GLYCOSYLTRANSFERASE INHIBITORS AND METHODS OF USE MAN2B1, GAA, GBA1 UGT8 74/4885PIK3CD 2351/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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