Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 4/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2182424 | 0.82 | MEN1 (0.45) | MEN1KMT2AGAASMN1; SMN2GPR35 | |
| SCHEMBL21061047 | 0.82 | NOTUM (0.50) | NOTUMMEN1KMT2AGAACETP | |
| SCHEMBL10387262 | 0.81 | SMN1; SMN2 (0.47) | MEN1KMT2AGAASMN1; SMN2NPSR1 | |
| SCHEMBL2184766 | 0.80 | MEN1 (0.43) | MEN1KMT2AGAASMN1; SMN2GPR35 | |
| SCHEMBL5281345 | 0.80 | MEN1 (0.48) | MEN1KMT2AGAASMN1; SMN2NPSR1 | |
| SCHEMBL15475549 | 0.75 | KMT2A (0.48) | MEN1KMT2AGAASMN1; SMN2NPSR1 | |
| SCHEMBL13700788 | 0.75 | KMT2A (0.51) | MEN1KMT2AGAASMN1; SMN2NPSR1 | |
| SCHEMBL16460805 | 0.75 | MEN1 (0.49) | MEN1KMT2AGAASMN1; SMN2NPSR1 | |
| SCHEMBL19090858 | 0.74 | NOTUM (0.45) | NOTUMCETPGPR35KDM4EGLA | |
| SCHEMBL19067143 | 0.74 | NOTUM (0.45) | NOTUMCETPGPR35KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4655296-A1 | CBL-B INHIBITORS | Aurigene Oncology Limited (IN) | 2025-12-03 | — | — | EP | disclosed |
| WO-2024156938-A1 | CBL-B INHIBITORS | ORION CORPORATION (FI) | 2024-08-02 | — | — | WO | disclosed |
| US-11427591-B2 | Kinase inhibitors | INSILICO MEDICINE IP LIMITED (HK) | 2022-08-30 | — | — | US | disclosed |
| WO-2020079652-A1 | KINASE INHIBITORS | Insilico Medicine Hong Kong Limited (CN) | 2020-04-23 | — | — | WO | disclosed |
| US-20200123165-A1 | KINASE INHIBITORS | INSILICO MEDICINE LTD. (CN) | 2020-04-23 | — | — | US | disclosed |
| US-20110166132-A1 | Gamma Secretase Modulators | AMGEN INC. (US) | 2011-07-07 | — | — | US | disclosed |
| EP-2231602-A1 | GAMMA SECRETASE MODULATORS | Amgen, Inc (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009075874-A1 | GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11427591-B2 | Kinase inhibitors | DDR1, DDR2, DDRGK1 | NOTUM 4573/4885MEN1 716/4885KMT2A 1514/4885 |
| US-20110166132-A1 | Gamma Secretase Modulators | BACE1, BACE2, PSEN1 | NOTUM 836/4885MEN1 2950/4885KMT2A 3574/4885 |
| US-20200123165-A1 | KINASE INHIBITORS | DDR1, DDR2, DDRGK1 | NOTUM 4573/4885MEN1 716/4885KMT2A 1514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.