Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1268774 | 0.83 | PAK4 (0.48) | PLK4PAK4MEN1KMT2AHSD17B10 | |
| SCHEMBL2169069 | 0.79 | GRK6 (0.39) | PLK4PAK4IGF1R | |
| SCHEMBL1269791 | 0.79 | IGF1R (0.39) | PLK4PAK4IGF1R | |
| SCHEMBL2148630 | 0.79 | AURKA (0.32) | — | |
| SCHEMBL1270410 | 0.78 | HCAR2 (0.42) | PLK4PAK4KDM4ENPC1MAPT | |
| SCHEMBL1268810 | 0.78 | IGF1R (0.44) | PAK4IGF1R | |
| SCHEMBL1270530 | 0.77 | IGF1R (0.35) | PLK4PAK4IGF1R | |
| SCHEMBL3932730 | 0.76 | HCAR2 (0.31) | PLK4PAK4KDM4EALDH1A1 | |
| SCHEMBL1269811 | 0.76 | LCK (0.42) | PAK4IGF1R | |
| SCHEMBL1269825 | 0.76 | PLK4 (0.31) | PLK4PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |