Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.70 |
| ▸ | JAK1 | P23458 | 13/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23678568 | 0.94 | JAK1 (0.70) | JAK2JAK1 | |
| SCHEMBL23678576 | 0.93 | JAK2 (0.61) | JAK2JAK1KCNH2 | |
| SCHEMBL23678678 | 0.90 | JAK1 (0.61) | JAK2JAK1 | |
| SCHEMBL21870760 | 0.90 | JAK2 (0.79) | JAK2JAK1 | |
| SCHEMBL21871381 | 0.90 | JAK1 (0.88) | JAK2JAK1 | |
| SCHEMBL21870714 | 0.90 | JAK1 (0.88) | JAK2JAK1 | |
| SCHEMBL21870787 | 0.90 | JAK1 (0.88) | JAK2JAK1 | |
| SCHEMBL21870717 | 0.90 | JAK2 (0.75) | JAK2JAK1 | |
| SCHEMBL24065872 | 0.87 | JAK1 (0.88) | JAK2JAK1 | |
| SCHEMBL23678717 | 0.86 | JAK1 (0.61) | JAK2JAK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3854793-A1 | AROMATIC HETEROCYCLIC COMPOUND WITH KINASE INHIBITORY ACTIVITY | Shanghai Ennovabio Pharmaceuticals Co., Ltd. (CN) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020057669-A1 | AROMATIC HETEROCYCLIC COMPOUND WITH KINASE INHIBITORY ACTIVITY | 上海轶诺药业有限公司 | 2020-03-26 | — | — | WO | disclosed |