Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 4/20 | 0.79 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.79 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186444 | 0.83 | CSNK1E (0.79) | CSNK1ECSNK1DCSNK1G3NPC1RAB9A | |
| SCHEMBL2187404 | 0.80 | CSNK1E (0.65) | CSNK1ECSNK1DCSNK1G3NPC1RAB9A | |
| SCHEMBL16789316 | 0.78 | CSNK1E (0.60) | CSNK1ECSNK1DCSNK1G3NPC1RAB9A | |
| SCHEMBL27730042 | 0.77 | CSNK1E (0.59) | CSNK1ECSNK1DCSNK1G3KCNK3KCNK9 | |
| SCHEMBL16767400 | 0.75 | CSNK1E (0.82) | CSNK1ECSNK1DCSNK1G3NPC1RAB9A | |
| SCHEMBL11705432 | 0.73 | IRAK4 (0.58) | NPC1RAB9APKMHSP90AA1PAX8 | |
| SCHEMBL2187132 | 0.73 | CSNK1E (0.54) | CSNK1ECSNK1DCSNK1G3ABL1LMNA | |
| SCHEMBL2187408 | 0.72 | CSNK1E (0.55) | CSNK1ECSNK1DCSNK1G3NPC1RAB9A | |
| SCHEMBL16766870 | 0.72 | CSNK1E (1.00) | CSNK1ECSNK1DCSNK1G3NPC1RAB9A | |
| SCHEMBL28775420 | 0.71 | CSNK1E (0.84) | CSNK1ECSNK1DCSNK1G3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |