Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 20/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18055525 | 1.00 | HTRA1 (0.49) | HTRA1 | |
| SCHEMBL19665826 | 1.00 | HTRA1 (0.49) | HTRA1 | |
| SCHEMBL21882747 | 0.90 | HTRA1 (0.60) | HTRA1 | |
| SCHEMBL18055506 | 0.90 | HTRA1 (0.60) | HTRA1 | |
| SCHEMBL19665816 | 0.86 | HTRA1 (0.64) | HTRA1 | |
| SCHEMBL19665814 | 0.86 | HTRA1 (0.64) | HTRA1 | |
| SCHEMBL21882757 | 0.85 | HTRA1 (0.54) | HTRA1 | |
| SCHEMBL18055516 | 0.85 | HTRA1 (0.54) | HTRA1 | |
| SCHEMBL19665838 | 0.85 | HTRA1 (0.54) | HTRA1 | |
| SCHEMBL18039147 | 0.83 | HTRA1 (0.39) | HTRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262026-B1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2020-03-18 | — | — | EP | disclosed |