Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.67 |
| ▸ | LCK | P06239 | 1/20 | 0.67 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.60 |
| ▸ | JAK3 | P52333 | 2/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903094 | 0.90 | EGFR (0.74) | EGFRERBB2LCKERBB4JAK3 | |
| SCHEMBL11903198 | 0.90 | EGFR (0.74) | EGFRERBB2LCKERBB4JAK3 | |
| SCHEMBL7236445 | 0.83 | EGFR (0.81) | EGFRERBB2LCKERBB4AURKA | |
| SCHEMBL17485154 | 0.83 | EGFR (0.61) | EGFRERBB2LCKERBB4JAK3 | |
| SCHEMBL11902491 | 0.82 | ERBB2 (0.63) | EGFRERBB2LCKERBB4AURKA | |
| SCHEMBL7235104 | 0.82 | EGFR (0.77) | EGFRERBB2LCKERBB4AURKA | |
| SCHEMBL30125835 | 0.82 | ERBB2 (0.68) | EGFRERBB2LCKERBB4AURKA | |
| SCHEMBL11903417 | 0.81 | EGFR (0.74) | EGFRERBB2LCKERBB4JAK3 | |
| SCHEMBL11903105 | 0.81 | EGFR (0.74) | EGFRERBB2LCKERBB4JAK3 | |
| SCHEMBL11903415 | 0.81 | EGFR (0.74) | EGFRERBB2LCKERBB4JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020055643-A2 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HER-DRIVEN CANCERS | RAIN THERAPEUTICS INC. (US) | 2020-03-19 | — | — | WO | disclosed |