Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21884541 | 0.78 | PPIA (0.33) | PPIA | |
| SCHEMBL21884384 | 0.78 | AR (0.34) | PPIACHRM1 | |
| SCHEMBL21884633 | 0.67 | CCNT1 (0.39) | NR3C1 | |
| SCHEMBL15402236 | 0.63 | CFTR (0.43) | CYP2C9NR3C1CHRM1 | |
| SCHEMBL21884538 | 0.63 | PPIA (0.35) | PPIABDKRB1ADORA1 | |
| SCHEMBL21884497 | 0.63 | PPIA (0.35) | PPIA | |
| SCHEMBL21884467 | 0.62 | PPIA (0.38) | PPIA | |
| SCHEMBL7449035 | 0.61 | PDE10A (0.41) | CYP2C9NR3C1CHRM1 | |
| SCHEMBL15402235 | 0.61 | NPC1 (0.40) | CYP2C9NR3C1CHRM1 | |
| SCHEMBL21884563 | 0.61 | PPIA (0.37) | PPIABDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020061473-A1 | SMALL MOLECULES TARGETING MUTANT MAMMALIAN PROTEINS | JNANA THERAPEUTICS, INC. (US) | 2020-03-26 | — | — | WO | disclosed |