Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.52 |
| ▸ | KDR | P35968 | 8/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 3/20 | 0.39 |
| ▸ | FLT4 | P35916 | 3/20 | 0.39 |
| ▸ | MET | P08581 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | TEK | Q02763 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30365202 | 1.00 | EGFR (0.52) | EGFRKDRSRCDRD2ERBB2 | |
| SCHEMBL21885569 | 0.91 | EGFR (0.53) | EGFRKDRSRCDRD2ERBB2 | |
| SCHEMBL30365078 | 0.91 | EGFR (0.53) | EGFRKDRSRCDRD2ERBB2 | |
| SCHEMBL21884874 | 0.88 | EGFR (0.55) | EGFRKDRSRCDRD2ERBB2 | |
| SCHEMBL21884858 | 0.87 | KDR (0.51) | EGFRKDRSRCDRD2ERBB2 | |
| SCHEMBL30364938 | 0.82 | KDR (0.59) | EGFRKDRSRCDRD2ERBB2 | |
| SCHEMBL21886113 | 0.82 | KDR (0.59) | EGFRKDRSRCDRD2ERBB2 | |
| SCHEMBL21886111 | 0.82 | KDR (0.59) | EGFRKDRSRCDRD2ERBB2 | |
| SCHEMBL21886100 | 0.82 | KDR (0.59) | EGFRKDRSRCDRD2ERBB2 | |
| SCHEMBL30365096 | 0.82 | KDR (0.59) | EGFRKDRSRCDRD2ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020057403-A1 | INDOLE DERIVATIVE AND MEDICAL APPLICATION THEREOF | 北京越之康泰生物医药科技有限公司 | 2020-03-26 | — | — | WO | disclosed |