Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.75 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.75 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.54 |
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.54 |
| ▸ | FLT3 | P36888 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.54 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
| ▸ | ERN1 | O75460 | 1/20 | 0.54 |
| ▸ | STK10 | O94804 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18265416 | 0.94 | KDR (0.77) | KDRPDGFRBRETPDGFRASRC | |
| SCHEMBL21884843 | 0.91 | KDR (0.74) | KDRPDGFRBRETPDGFRASRC | |
| SCHEMBL28872425 | 0.91 | KDR (0.77) | KDRPDGFRBRETPDGFRASRC | |
| SCHEMBL10296342 | 0.89 | KDR (0.71) | KDRPDGFRBRETPDGFRASRC | |
| SCHEMBL10296339 | 0.89 | KDR (0.71) | KDRPDGFRBRETPDGFRASRC | |
| SCHEMBL18265408 | 0.89 | KDR (0.68) | KDRPDGFRBRETPDGFRASRC | |
| SCHEMBL21884868 | 0.88 | KDR (0.60) | KDRPDGFRBRETPDGFRASRC | |
| SCHEMBL10296340 | 0.88 | KDR (0.70) | KDRPDGFRBRETPDGFRASRC | |
| SCHEMBL31484770 | 0.88 | KDR (0.70) | KDRPDGFRBRETPDGFRASRC | |
| SCHEMBL4451546 | 0.88 | KDR (0.73) | KDRPDGFRBRETPDGFRASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020057403-A1 | INDOLE DERIVATIVE AND MEDICAL APPLICATION THEREOF | 北京越之康泰生物医药科技有限公司 | 2020-03-26 | — | — | WO | disclosed |