Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.69 |
| ▸ | STAT3 | P40763 | 1/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21887328 | 0.92 | TYK2 (0.66) | TYK2STAT3PDE4DJAK1 | |
| SCHEMBL29746678 | 0.88 | TYK2 (0.77) | TYK2STAT3PDE4D | |
| SCHEMBL22342898 | 0.88 | TYK2 (0.77) | TYK2STAT3PDE4D | |
| SCHEMBL30349558 | 0.86 | TYK2 (0.61) | TYK2STAT3PDE4DJAK1 | |
| SCHEMBL21811191 | 0.86 | TYK2 (0.61) | TYK2STAT3PDE4DJAK1 | |
| SCHEMBL21726387 | 0.86 | TYK2 (0.80) | TYK2PDE4DJAK1 | |
| SCHEMBL22343286 | 0.85 | TYK2 (0.72) | TYK2STAT3PDE4DJAK1 | |
| SCHEMBL23327701 | 0.84 | TYK2 (0.56) | TYK2STAT3PDE4DJAK1 | |
| SCHEMBL30548451 | 0.84 | TYK2 (0.56) | TYK2STAT3PDE4DJAK1 | |
| SCHEMBL21887357 | 0.84 | TYK2 (0.58) | TYK2STAT3PDE4DJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849981-B1 | PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSORIASIS AND SYSTEMIC LUPUS ERYTHEMATOSUS | LILLY CO ELI (US) | 2023-02-01 | — | — | EP | disclosed |
| WO-2020055636-A1 | PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSORIASIS AND SYSTEMIC LUPUS ERYTHEMATOSUS | ELI LILLY AND COMPANY (US) | 2020-03-19 | — | — | WO | disclosed |