Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.48 |
| ▸ | PI4KA | P42356 | 1/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29405390 | 1.00 | MKNK1 (0.49) | MKNK1MKNK2PIK3CDPIK3CAPIK3CG | |
| SCHEMBL29371526 | 0.79 | PIK3CD (0.53) | MKNK1MKNK2PIK3CDPIK3CAPIK3CG | |
| SCHEMBL21876209 | 0.79 | PIK3CD (0.53) | MKNK1MKNK2PIK3CDPIK3CAPIK3CG | |
| SCHEMBL22165237 | 0.77 | PIK3CD (0.55) | MKNK1MKNK2PIK3CDPIK3CAPIK3CG | |
| SCHEMBL29401966 | 0.75 | PIK3CD (0.44) | MKNK1MKNK2PIK3CDPIK3CAPIK3CG | |
| SCHEMBL31705611 | 0.75 | MKNK1 (0.51) | MKNK1MKNK2PIK3CDPIK3CAPIK3CG | |
| SCHEMBL21819049 | 0.73 | KIT (0.36) | MKNK1MKNK2KDM5BIRAK4DYRK1B | |
| SCHEMBL21887565 | 0.72 | PIK3CD (0.44) | MKNK1MKNK2PIK3CDPIK3CAPIK3CG | |
| SCHEMBL574538 | 0.72 | — | — | |
| SCHEMBL21471881 | 0.72 | CREBBP (0.49) | MKNK1MKNK2PIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020061112-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. (US) | 2020-03-26 | — | — | WO | disclosed |