Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 11/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 10/20 | 1.00 |
| ▸ | FGFR2 | P21802 | 10/20 | 1.00 |
| ▸ | FGFR3 | P22607 | 8/20 | 1.00 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.70 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.70 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.70 |
| ▸ | HAMP | P81172 | 2/20 | 0.70 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21808630 | 1.00 | ACVR1 (1.00) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL30767266 | 0.90 | ACVR1 (0.82) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL21808525 | 0.85 | FGFR2 (0.82) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL21846698 | 0.83 | FGFR2 (1.00) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL30767265 | 0.80 | ACVR1 (0.72) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL30767259 | 0.79 | FGFR2 (0.73) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL30767254 | 0.78 | ACVR1 (0.75) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL21808276 | 0.77 | FGFR2 (0.83) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL21891889 | 0.76 | ACVR1 (1.00) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL21808263 | 0.76 | ACVR1 (1.00) | ACVR1FGFR1FGFR2FGFR3BMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020068729-A1 | PYRAZOLO[4,3-D]PYRIMIDINE COMPOUNDS AS ALK2 ABD/OR FGFR MODULATORS | INCYTE CORPORATION (US) | 2020-04-02 | — | — | WO | disclosed |