Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 19/20 | 0.79 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15938336 | 0.89 | MAPK3 (1.00) | MAPK3 | |
| SCHEMBL15938436 | 0.81 | MAPK3 (0.81) | MAPK3 | |
| SCHEMBL15938730 | 0.80 | MAPK3 (1.00) | MAPK3 | |
| SCHEMBL15938329 | 0.80 | MAPK3 (0.84) | MAPK3 | |
| SCHEMBL17102729 | 0.79 | MAPK3 (0.80) | MAPK3 | |
| SCHEMBL15938084 | 0.79 | MAPK3 (0.72) | MAPK3 | |
| SCHEMBL15948641 | 0.78 | MAPK3 (0.79) | MAPK3 | |
| SCHEMBL15948505 | 0.78 | MAPK3 (0.92) | MAPK3 | |
| SCHEMBL17102733 | 0.78 | MAPK3 (0.78) | MAPK3 | |
| SCHEMBL15948515 | 0.77 | MAPK3 (1.00) | MAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2953457-B1 | ERK INHIBITORS AND USES THEREOF | CELGENE CAR LLC (BM) | 2020-04-08 | — | — | EP | disclosed |