Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 19/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.61 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.61 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15938232 | 0.88 | MAPK3 (0.66) | MAPK3MAPK1MAP2K1MAP3K7FGFR1 | |
| SCHEMBL21894054 | 0.85 | MAPK3 (0.70) | MAPK3MAPK1MAP2K1MAP3K7FGFR1 | |
| SCHEMBL21894063 | 0.82 | MAPK3 (0.72) | MAPK3MAPK1 | |
| SCHEMBL15938580 | 0.79 | MAPK3 (0.66) | MAPK3MAPK1MAP2K1MAP3K7FGFR1 | |
| SCHEMBL15938499 | 0.78 | MAPK3 (1.00) | MAPK3MAPK1 | |
| SCHEMBL15946673 | 0.77 | MAPK3 (1.00) | MAPK3MAPK1 | |
| SCHEMBL15938421 | 0.77 | MAPK3 (1.00) | MAPK3MAPK1 | |
| SCHEMBL15938424 | 0.77 | MAPK3 (1.00) | MAPK3MAPK1 | |
| SCHEMBL15938827 | 0.77 | MAPK3 (1.00) | MAPK3MAPK1 | |
| SCHEMBL17616270 | 0.77 | MAPK3 (0.84) | MAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2953457-B1 | ERK INHIBITORS AND USES THEREOF | CELGENE CAR LLC (BM) | 2020-04-08 | — | — | EP | disclosed |