Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 17/20 | 0.81 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21894347 | 1.00 | MAPK3 (0.81) | MAPK3LRRK2FGFR4KDRAURKB | |
| SCHEMBL19176602 | 0.98 | MAPK3 (0.84) | MAPK3LRRK2FGFR4KDRAURKB | |
| SCHEMBL19176554 | 0.98 | MAPK3 (0.84) | MAPK3LRRK2FGFR4KDRAURKB | |
| SCHEMBL19176670 | 0.98 | MAPK3 (0.84) | MAPK3LRRK2FGFR4KDRAURKB | |
| SCHEMBL18857671 | 0.98 | MAPK3 (0.82) | MAPK3LRRK2FGFR4KDRAURKB | |
| SCHEMBL18469824 | 0.96 | MAPK3 (0.82) | MAPK3LRRK2FGFR4 | |
| SCHEMBL15937976 | 0.91 | MAPK3 (0.97) | MAPK3LRRK2FGFR4KDRAURKB | |
| SCHEMBL15938571 | 0.90 | MAPK3 (1.00) | MAPK3LRRK2FGFR4KDRAURKB | |
| SCHEMBL15938881 | 0.90 | MAPK3 (1.00) | MAPK3LRRK2FGFR4KDRAURKB | |
| SCHEMBL15938250 | 0.90 | MAPK3 (1.00) | MAPK3LRRK2FGFR4KDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2953457-B1 | ERK INHIBITORS AND USES THEREOF | CELGENE CAR LLC (BM) | 2020-04-08 | — | — | EP | disclosed |