Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29903488 | 1.00 | KDM4E (0.36) | KDM4EPOLBL3MBTL1ALDH1A1PKM | |
| SCHEMBL21254357 | 1.00 | KDM4E (0.36) | KDM4EPOLBL3MBTL1ALDH1A1PKM | |
| SCHEMBL21899167 | 0.98 | KDM4E (0.35) | KDM4EPOLBL3MBTL1ALDH1A1PKM | |
| SCHEMBL18783127 | 0.98 | KDM4E (0.35) | KDM4EPOLBL3MBTL1ALDH1A1PKM | |
| SCHEMBL14652992 | 0.68 | CA1 (0.32) | ALDH1A1PKMLMNATSHRPARP1 | |
| SCHEMBL14652809 | 0.63 | PARP1 (0.36) | LMNATSHRPARP1 | |
| SCHEMBL774979 | 0.62 | — | — | |
| SCHEMBL10646748 | 0.62 | — | — | |
| SCHEMBL12380067 | 0.62 | — | — | |
| SCHEMBL12380168 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081636-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2020-04-23 | — | — | WO | disclosed |