Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.67 |
| ▸ | JAK3 | P52333 | 17/20 | 0.61 |
| ▸ | JAK1 | P23458 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18599148 | 0.94 | BTK (0.59) | BTKJAK3JAK1EGFR | |
| SCHEMBL18618516 | 0.90 | BTK (0.67) | BTKJAK3JAK1EGFR | |
| SCHEMBL19533468 | 0.85 | JAK3 (0.68) | BTKJAK3JAK1EGFR | |
| SCHEMBL18619675 | 0.84 | BTK (0.61) | BTKJAK3JAK1EGFR | |
| SCHEMBL18619676 | 0.84 | BTK (0.61) | BTKJAK3JAK1EGFR | |
| SCHEMBL20375120 | 0.84 | BTK (0.67) | BTKJAK3JAK1EGFR | |
| SCHEMBL19623270 | 0.83 | BTK (0.51) | BTKJAK3JAK1EGFR | |
| SCHEMBL21900774 | 0.83 | BTK (0.51) | BTKJAK3JAK1EGFR | |
| SCHEMBL19243856 | 0.83 | BTK (0.51) | BTKJAK3JAK1EGFR | |
| SCHEMBL21900776 | 0.83 | BTK (0.47) | BTKJAK3JAK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3257855-B1 | METHOD FOR PREPARING IBRUTINIB | SHANGHAI DUDE MEDICAL SCIENCE AND TECH CO LTD (CN) | 2020-04-22 | — | — | EP | disclosed |