Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 18/20 | 0.60 |
| ▸ | SMARCA2 | P51531 | 15/20 | 0.60 |
| ▸ | SMARCA4 | P51532 | 15/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 9/20 | 0.60 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18081005 | 0.88 | PBRM1 (0.69) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL30606976 | 0.88 | PBRM1 (0.69) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL18081211 | 0.85 | PBRM1 (0.65) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL30606986 | 0.80 | PBRM1 (0.61) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL18080928 | 0.80 | PBRM1 (0.61) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL21901730 | 0.80 | PBRM1 (0.60) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL18080989 | 0.80 | PBRM1 (0.60) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL31101965 | 0.79 | PBRM1 (0.53) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL30241744 | 0.78 | PBRM1 (0.70) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL26148109 | 0.78 | PBRM1 (0.70) | PBRM1SMARCA2SMARCA4NR1I2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020078933-A1 | PROTEOLYSIS TARGETING CHIMERA (PROTACS) AS DEGRADERS OF SMARCA2 AND/OR SMARCA4 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-04-23 | — | — | WO | disclosed |