Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.77 |
| ▸ | AKT2 | P31751 | 14/20 | 0.77 |
| ▸ | AKT3 | Q9Y243 | 9/20 | 0.74 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2189888 | 0.92 | AKT1 (0.84) | AKT1AKT2AKT3CYP2C8CYP2C9 | |
| SCHEMBL2193736 | 0.89 | AKT1 (0.83) | AKT1AKT2AKT3CYP2C8CYP2C9 | |
| SCHEMBL12419616 | 0.88 | AKT1 (0.68) | AKT1AKT2AKT3CYP2C8CYP2C9 | |
| SCHEMBL2194082 | 0.88 | AKT1 (0.83) | AKT1AKT2AKT3CYP2C8CYP2C9 | |
| SCHEMBL2175106 | 0.87 | AKT1 (1.00) | AKT1AKT2AKT3CYP2C8CYP2C9 | |
| SCHEMBL2173895 | 0.87 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL2177893 | 0.86 | AKT1 (0.91) | AKT1AKT2AKT3CYP2C8CYP2C9 | |
| SCHEMBL2176420 | 0.86 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL2193720 | 0.85 | AKT1 (0.88) | AKT1AKT2AKT3CYP2C8CYP2C9 | |
| SCHEMBL2192080 | 0.85 | AKT1 (0.92) | AKT1AKT2AKT3CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519522-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ArQule, Inc. (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011082270-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE. INC. (US) | 2011-07-07 | — | — | WO | disclosed |