Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 20/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | FGR | P09769 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21907249 | 0.86 | RET (0.57) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL21907135 | 0.85 | RET (0.56) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL21907169 | 0.84 | RET (0.55) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL21907176 | 0.84 | RET (0.57) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL21907254 | 0.83 | RET (0.59) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL29681435 | 0.83 | RET (0.59) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL24345128 | 0.83 | RET (0.52) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL21907178 | 0.83 | RET (0.52) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL21907179 | 0.83 | RET (0.52) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL24490700 | 0.83 | RET (0.52) | RETCYP1A2HCKFGRRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849986-B1 | FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2022-06-08 | — | — | EP | disclosed |
| WO-2020055672-A1 | FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2020-03-19 | — | — | WO | disclosed |