SCHEMBL21912982

SCHEMBL21912982

CCCN(CCC)C(=O)C1=Cc2ccc(-c3ccc(C(=O)OCc4ccccc4)cc3)cc2N=C(NC(=O)OC(C)(C)C)C1

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 20/20 0.67
TLR7 Q9NYK1 6/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21912241 0.89 TLR8 (0.72) TLR8TLR7
SCHEMBL1801998 0.87 TLR8 (0.64) TLR8TLR7
SCHEMBL1237680 0.84 TLR8 (0.60) TLR8TLR7
SCHEMBL1588676 0.84 TLR8 (0.66) TLR8TLR7
SCHEMBL18041313 0.84 TLR8 (0.67) TLR8TLR7
SCHEMBL18041391 0.83 TLR8 (0.66) TLR8TLR7
SCHEMBL18640255 0.82 TLR8 (0.69) TLR8TLR7
SCHEMBL18041410 0.81 TLR8 (0.64) TLR8TLR7
SCHEMBL28472239 0.81 TLR8 (0.69) TLR8TLR7
SCHEMBL21065724 0.81 TLR8 (0.63) TLR8TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020056198-A2 SUBSTITUTED BENZAZEPINE COMPOUNDS, CONJUGATES, AND USES THEREOF SILVERBACK THERAPEUTICS, INC. (US) 2020-03-19 WO disclosed