Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLP1R | P43220 | 4/20 | 0.44 |
| ▸ | SCTR | P47872 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 3/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.41 |
| ▸ | NPY4R | P50391 | 8/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 7/20 | 0.40 |
| ▸ | NPY1R | P25929 | 6/20 | 0.40 |
| ▸ | NPY2R | P49146 | 4/20 | 0.40 |
| ▸ | VIPR2 | P41587 | 2/20 | 0.40 |
| ▸ | VIPR1 | P32241 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2183301 | 0.93 | NPY4R (0.46) | NPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL30512578 | 0.85 | GLP1R (0.48) | GLP1RSCTRBACE1VIPR2VIPR1 | |
| SCHEMBL29659741 | 0.85 | NPY4R (0.47) | GLP1RSCTRNPY4RNPY5RNPY1R | |
| SCHEMBL30475877 | 0.84 | NPY4R (0.46) | NPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL30543172 | 0.84 | NPY4R (0.47) | GLP1RSCTRNPY4RNPY5RNPY1R | |
| SCHEMBL31516403 | 0.84 | GLP1R (0.49) | GLP1RSCTRKEAP1VIPR2VIPR1 | |
| SCHEMBL30262179 | 0.83 | GLP1R (0.51) | GLP1RSCTRVIPR2VIPR1 | |
| SCHEMBL29659755 | 0.83 | GLP1R (0.47) | GLP1RSCTRNPY4RNPY5RNPY1R | |
| SCHEMBL31307244 | 0.82 | GLP1R (0.51) | GLP1RSCTRKEAP1VIPR2VIPR1 | |
| SCHEMBL31064947 | 0.81 | BACE1 (0.55) | GLP1RSCTRBACE1BACE2NPY4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190070251-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NEKTAR THERAPEUTICS | 2019-03-07 | — | — | US | disclosed |
| US-9682153-B2 | Polymer conjugates of therapeutic peptides | NEKTAR THERAPEUTICS (US) | 2017-06-20 | — | — | US | disclosed |
| US-20160022828-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NEKTAR THERAPEUTICS | 2016-01-28 | — | — | US | disclosed |
| US-20110171312-A1 | MODIFIED THERAPEUTIC PEPTIDES, METHODS OF THEIR PREPARATION AND USE | NEKTAR THERAPEUTICS (US) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022828-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NGLY1, CD44, IAPP | GLP1R 323/4885SCTR 37/4885KEAP1 2406/4885 |
| US-20190070251-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NGLY1, CD44, IAPP | GLP1R 323/4885SCTR 37/4885KEAP1 2406/4885 |
| US-20110171312-A1 | MODIFIED THERAPEUTIC PEPTIDES, METHODS OF THEIR PREPARATION AND USE | DNPEP, VIP, PTMS | GLP1R 233/4885SCTR 15/4885KEAP1 3263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.