Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 18/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21921455 | 1.00 | MAP4K1 (0.50) | MAP4K1CYP3A4PTPN11 | |
| SCHEMBL30087811 | 1.00 | MAP4K1 (0.50) | MAP4K1CYP3A4PTPN11 | |
| SCHEMBL21921372 | 0.92 | MAP4K1 (0.52) | MAP4K1CYP3A4 | |
| SCHEMBL21919993 | 0.90 | MAP4K1 (0.39) | MAP4K1CYP3A4 | |
| SCHEMBL30087899 | 0.86 | MAP4K1 (0.39) | MAP4K1CYP3A4 | |
| SCHEMBL21920800 | 0.86 | MAP4K1 (0.39) | MAP4K1CYP3A4 | |
| SCHEMBL21921480 | 0.84 | MAP4K1 (0.43) | MAP4K1CYP3A4 | |
| SCHEMBL21919979 | 0.84 | MAP4K1 (0.43) | MAP4K1CYP3A4 | |
| SCHEMBL21920570 | 0.84 | MAP4K1 (0.40) | MAP4K1CYP3A4 | |
| SCHEMBL21920330 | 0.84 | MAP4K1 (0.42) | MAP4K1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113015526-A | Spirocyclic 2, 3-dihydro-7-azaindole compounds and uses thereof | 豪夫迈·罗氏有限公司 | 2021-06-22 | — | — | CN | disclosed |
| WO-2020061377-A1 | SPIROCYCLIC 2,3-DIHYDRO-7-AZAINDOLE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2020-03-26 | — | — | WO | disclosed |