Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.59 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.59 |
| ▸ | MTOR | P42345 | 15/20 | 0.54 |
| ▸ | RICTOR | Q6R327 | 5/20 | 0.54 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.54 |
| ▸ | MAPKAP1 | Q9BPZ7 | 5/20 | 0.54 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.54 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.54 |
| ▸ | PRKDC | P78527 | 2/20 | 0.54 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.54 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21929432 | 0.90 | PIK3CA (0.59) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929468 | 0.90 | PIK3CA (0.55) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929580 | 0.88 | PIK3CA (0.58) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929453 | 0.88 | PIK3CA (0.58) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929439 | 0.87 | PIK3CA (0.55) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929671 | 0.87 | PIK3CA (0.55) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929587 | 0.87 | PIK3CA (0.54) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929433 | 0.86 | PIK3CA (0.53) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929452 | 0.86 | PIK3CA (0.61) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929673 | 0.85 | PIK3CA (0.58) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3643717-A1 | 7-SITE SUBSTITUTED PYRROLE TRIAZINE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND PREPARATION METHOD THEREFOR AND USES THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2020-04-29 | — | — | EP | disclosed |