Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.63 |
| ▸ | PIK3R1 | P27986 | 11/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.60 |
| ▸ | RAF1 | P04049 | 1/20 | 0.60 |
| ▸ | MTOR | P42345 | 5/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21929585 | 0.97 | PIK3CA (0.65) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| SCHEMBL21929464 | 0.91 | PIK3CA (0.75) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| SCHEMBL21929467 | 0.91 | PIK3CA (0.65) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| SCHEMBL22006217 | 0.90 | PIK3CA (0.76) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| SCHEMBL21929463 | 0.89 | PIK3CA (0.75) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| SCHEMBL21929583 | 0.88 | PIK3CA (0.77) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| SCHEMBL21929596 | 0.85 | PIK3CA (0.66) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| SCHEMBL21929462 | 0.85 | PIK3CA (0.77) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| SCHEMBL21929461 | 0.83 | PIK3CA (0.73) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| SCHEMBL21929470 | 0.80 | PIK3CA (0.52) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3643717-A1 | 7-SITE SUBSTITUTED PYRROLE TRIAZINE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND PREPARATION METHOD THEREFOR AND USES THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2020-04-29 | — | — | EP | disclosed |