Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.54 |
| ▸ | PIK3R1 | P27986 | 9/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.53 |
| ▸ | MTOR | P42345 | 6/20 | 0.47 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.47 |
| ▸ | PRKDC | P78527 | 2/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.47 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | FGR | P09769 | 1/20 | 0.47 |
| ▸ | FER | P16591 | 1/20 | 0.47 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TEC | P42680 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21929466 | 1.00 | PIK3CA (0.54) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21933482 | 0.91 | PIK3CA (0.55) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929432 | 0.89 | PIK3CA (0.59) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL22006205 | 0.89 | PIK3CA (0.53) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929582 | 0.88 | PIK3CA (0.53) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929580 | 0.87 | PIK3CA (0.58) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929453 | 0.87 | PIK3CA (0.58) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929663 | 0.87 | PIK3CA (0.55) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL23434839 | 0.86 | PIK3CA (0.49) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929578 | 0.85 | PIK3CA (0.56) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3643717-B1 | 7-SUBSTITUTED PYRROLE TRIAZINE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND PREPARATION METHOD THEREFOR AND USES THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2021-06-02 | — | — | EP | disclosed |
| EP-3643717-A1 | 7-SITE SUBSTITUTED PYRROLE TRIAZINE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND PREPARATION METHOD THEREFOR AND USES THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2020-04-29 | — | — | EP | disclosed |