Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | LIPG | Q9Y5X9 | 6/20 | 0.43 |
| ▸ | LPL | P06858 | 5/20 | 0.43 |
| ▸ | F11 | P03951 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.39 |
| ▸ | P4HB | P07237 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | CA9 | Q16790 | 4/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3502436 | 0.89 | ROCK1 (0.46) | ROCK1LIPGLPLF11F2 | |
| SCHEMBL794033 | 0.84 | ROCK1 (0.48) | ROCK1LIPGLPLF11F2 | |
| SCHEMBL1130871 | 0.84 | ROCK1 (0.48) | ROCK1LIPGLPLF11F2 | |
| SCHEMBL16035253 | 0.82 | ROCK1 (0.47) | ROCK1LIPGLPLF11F2 | |
| SCHEMBL1044923 | 0.82 | ROCK1 (0.47) | ROCK1LIPGLPLF11F2 | |
| SCHEMBL15594472 | 0.80 | ROCK1 (0.46) | ROCK1LIPGLPLF11F2 | |
| SCHEMBL793338 | 0.80 | ROCK1 (0.48) | ROCK1LIPGLPLF11F2 | |
| SCHEMBL12069299 | 0.80 | ROCK1 (0.46) | ROCK1LIPGLPLF11F2 | |
| SCHEMBL516413 | 0.80 | ROCK1 (0.46) | ROCK1LIPGLPLF11F2 | |
| SCHEMBL28960278 | 0.80 | ROCK1 (0.46) | ROCK1LIPGLPLF11F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112601745-B | Azaaryl amide derivative and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-112601745-A | Azaaryl amide derivative and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2021-04-02 | — | — | CN | disclosed |
| WO-2020082921-A1 | NITROGEN HETEROARYL AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 上海和誉生物医药科技有限公司 | 2020-04-30 | — | — | WO | disclosed |