Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.80 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.69 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7454196 | 0.89 | LRRK2 (1.00) | LRRK2MAP3K9MKNK2 | |
| SCHEMBL7456067 | 0.89 | LRRK2 (0.77) | LRRK2MAP3K9MKNK2 | |
| SCHEMBL7452273 | 0.88 | LRRK2 (0.83) | LRRK2MAP3K9MKNK2 | |
| SCHEMBL7453397 | 0.86 | LRRK2 (1.00) | LRRK2MAP3K9MKNK2 | |
| SCHEMBL14556221 | 0.86 | LRRK2 (1.00) | LRRK2MAP3K9MKNK2 | |
| SCHEMBL7458201 | 0.86 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL12065483 | 0.85 | LRRK2 (1.00) | LRRK2MAP3K9MKNK2 | |
| SCHEMBL14556282 | 0.85 | LRRK2 (1.00) | LRRK2MAP3K9MKNK2 | |
| SCHEMBL7449911 | 0.84 | LRRK2 (1.00) | LRRK2MAP3K9MKNK2 | |
| SCHEMBL14556271 | 0.84 | LRRK2 (0.86) | LRRK2MAP3K9MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081682-A1 | DEGRADERS OF WILD-TYPE AND MUTANT FORMS OF LRRK2 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |