Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.85 |
| ▸ | IKZF3 | Q9UKT9 | 18/20 | 0.85 |
| ▸ | TNF | P01375 | 3/20 | 0.82 |
| ▸ | IL1B | P01584 | 3/20 | 0.82 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.82 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26318062 | 0.96 | CRBN (0.91) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL26321494 | 0.96 | CRBN (0.91) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL22243504 | 0.94 | CRBN (0.89) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL2252296 | 0.93 | CRBN (0.91) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL2252158 | 0.93 | CRBN (0.85) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL24146212 | 0.92 | CRBN (0.87) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL2249787 | 0.92 | CRBN (1.00) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL2249312 | 0.92 | CRBN (0.84) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL2248944 | 0.91 | CRBN (0.83) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL2252489 | 0.91 | CRBN (0.85) | CRBNIKZF3TNFIL1BIKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081682-A1 | DEGRADERS OF WILD-TYPE AND MUTANT FORMS OF LRRK2 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |