Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.55 |
| ▸ | ESYT2 | A0FGR8 | 1/20 | 0.55 |
| ▸ | HACL2 | A1L0T0 | 1/20 | 0.55 |
| ▸ | NBAS | A2RRP1 | 1/20 | 0.55 |
| ▸ | GTPBP10 | A4D1E9 | 1/20 | 0.55 |
| ▸ | CNOT1 | A5YKK6 | 1/20 | 0.55 |
| ▸ | TBKBP1 | A7MCY6 | 1/20 | 0.55 |
| ▸ | AGPS | O00116 | 1/20 | 0.55 |
| ▸ | ACOT7 | O00154 | 1/20 | 0.55 |
| ▸ | MYO1F | O00160 | 1/20 | 0.55 |
| ▸ | SNAP23 | O00161 | 1/20 | 0.55 |
| ▸ | HAX1 | O00165 | 1/20 | 0.55 |
| ▸ | AIP | O00170 | 1/20 | 0.55 |
| ▸ | AP3B1 | O00203 | 1/20 | 0.55 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.55 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.55 |
| ▸ | PSMD9 | O00233 | 1/20 | 0.55 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.55 |
| ▸ | PGRMC1 | O00264 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21942991 | 0.92 | BRAF (0.66) | BRAFPDGFRBESYT2HACL2NBAS | |
| SCHEMBL21944043 | 0.88 | BRAF (0.55) | BRAFPDGFRBESYT2HACL2NBAS | |
| SCHEMBL21943538 | 0.87 | BRAF (0.59) | BRAFPDGFRBESYT2HACL2NBAS | |
| SCHEMBL21943762 | 0.87 | BRAF (0.57) | BRAFPDGFRBESYT2HACL2NBAS | |
| SCHEMBL21943425 | 0.86 | MAPK14 (0.56) | BRAFPDGFRBESYT2HACL2NBAS | |
| SCHEMBL21943629 | 0.84 | MAPK14 (0.65) | BRAFPDGFRBESYT2HACL2NBAS | |
| SCHEMBL21944046 | 0.80 | BRAF (0.66) | BRAFPDGFRBESYT2HACL2NBAS | |
| SCHEMBL21943539 | 0.79 | BRAF (0.71) | BRAFPDGFRBESYT2HACL2NBAS | |
| SCHEMBL21943424 | 0.79 | BRAF (0.68) | BRAFPDGFRBESYT2HACL2NBAS | |
| SCHEMBL21943760 | 0.78 | BRAF (0.45) | BRAFPDGFRBESYT2HACL2NBAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11319322-B2 | Substituted aryl ether compound, preparation method thereof, pharmaceutical composition and use thereof | XIAMEN UNIVERSITY (CN) | 2022-05-03 | — | — | US | disclosed |
| US-20200123162-A1 | SUBSTITUTED ARYL ETHER COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | XIAMEN UNIVERSITY (CN) | 2020-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200123162-A1 | SUBSTITUTED ARYL ETHER COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | CYP4A11, CYP2D6, CYP3A43 | BRAF 95/4885PDGFRB 1488/4885ESYT2 4351/4885 |
| US-11319322-B2 | Substituted aryl ether compound, preparation method thereof, pharmaceutical composition and use thereof | CYP4A11, CYP2D6, CYP3A43 | BRAF 95/4885PDGFRB 1488/4885ESYT2 4351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.