Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 8/20 | 0.81 |
| ▸ | KIF5B | P33176 | 1/20 | 0.81 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.81 |
| ▸ | KIT | P10721 | 5/20 | 0.64 |
| ▸ | CSF1R | P07333 | 4/20 | 0.64 |
| ▸ | BRAF | P15056 | 3/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 5/20 | 0.62 |
| ▸ | LYN | P07948 | 1/20 | 0.60 |
| ▸ | BCR | P11274 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21942967 | 0.97 | RET (0.76) | RETKIF5BCCDC6KITCSF1R | |
| SCHEMBL21943343 | 0.94 | RET (0.70) | RETKIF5BCCDC6KITCSF1R | |
| SCHEMBL21942965 | 0.93 | RET (0.69) | RETKIF5BCCDC6KITCSF1R | |
| SCHEMBL21943651 | 0.91 | RET (0.67) | RETKIF5BCCDC6KITCSF1R | |
| SCHEMBL21942957 | 0.91 | RET (0.66) | RETKIF5BCCDC6KITCSF1R | |
| SCHEMBL21943655 | 0.91 | RET (0.66) | RETKIF5BCCDC6KITCSF1R | |
| SCHEMBL21943603 | 0.91 | RET (0.70) | RETKIF5BCCDC6KITCSF1R | |
| SCHEMBL21942970 | 0.90 | RET (0.66) | RETKIF5BCCDC6KITCSF1R | |
| SCHEMBL21943599 | 0.90 | RET (0.66) | RETKIF5BCCDC6KITCSF1R | |
| SCHEMBL21943034 | 0.90 | RET (0.66) | RETKIF5BCCDC6KITCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11319322-B2 | Substituted aryl ether compound, preparation method thereof, pharmaceutical composition and use thereof | XIAMEN UNIVERSITY (CN) | 2022-05-03 | — | — | US | disclosed |
| EP-3647313-A1 | SUBSTITUTED ARYL ETHER COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Xiamen University (CN) | 2020-05-06 | — | — | EP | disclosed |
| US-20200123162-A1 | SUBSTITUTED ARYL ETHER COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | XIAMEN UNIVERSITY (CN) | 2020-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200123162-A1 | SUBSTITUTED ARYL ETHER COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | CYP4A11, CYP2D6, CYP3A43 | RET 309/4885KIF5B 4826/4885CCDC6 2970/4885 |
| US-11319322-B2 | Substituted aryl ether compound, preparation method thereof, pharmaceutical composition and use thereof | CYP4A11, CYP2D6, CYP3A43 | RET 309/4885KIF5B 4826/4885CCDC6 2970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.