Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | BTK | Q06187 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | CKS1B | P61024 | 2/20 | 0.47 |
| ▸ | SKP1 | P63208 | 2/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.47 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 2/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21946316 | 0.90 | JAK3 (0.60) | JAK3LCKBTKEGFRCKS1B | |
| SCHEMBL21946882 | 0.90 | JAK3 (0.60) | JAK3LCKBTKEGFRCKS1B | |
| SCHEMBL24927487 | 0.90 | JAK3 (0.60) | JAK3LCKBTKEGFRCKS1B | |
| SCHEMBL31039916 | 0.90 | JAK3 (0.60) | JAK3LCKBTKEGFRCKS1B | |
| SCHEMBL21946753 | 0.85 | CKS1B (0.48) | JAK3LCKBTKEGFRCKS1B | |
| SCHEMBL21855375 | 0.85 | JAK3 (0.58) | JAK3LCKBTKEGFR | |
| SCHEMBL21946354 | 0.83 | JAK3 (0.56) | JAK3LCKBTKEGFRCKS1B | |
| SCHEMBL21946738 | 0.80 | JAK3 (0.47) | JAK3LCKBTKEGFRCKS1B | |
| SCHEMBL19824686 | 0.80 | JAK3 (0.74) | JAK3LCKBTKEGFRCKS1B | |
| SCHEMBL21946794 | 0.79 | JAK3 (0.77) | JAK3LCKBTKEGFRGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081450-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |