Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 19/20 | 0.60 |
| ▸ | LCK | P06239 | 17/20 | 0.54 |
| ▸ | BTK | Q06187 | 5/20 | 0.54 |
| ▸ | EGFR | P00533 | 10/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30011366 | 1.00 | JAK3 (0.60) | JAK3LCKBTKEGFR | |
| SCHEMBL21946352 | 0.96 | JAK3 (0.63) | JAK3LCKBTKEGFR | |
| SCHEMBL21855211 | 0.94 | JAK3 (0.66) | JAK3LCKBTKEGFR | |
| SCHEMBL30011108 | 0.92 | JAK3 (0.61) | JAK3LCKBTKEGFR | |
| SCHEMBL21855245 | 0.91 | JAK3 (0.55) | JAK3LCKBTKEGFR | |
| SCHEMBL21946733 | 0.90 | JAK3 (0.64) | JAK3LCKBTKEGFR | |
| SCHEMBL30011960 | 0.90 | BTK (0.64) | JAK3LCKBTKEGFR | |
| SCHEMBL21946803 | 0.90 | BTK (0.64) | JAK3LCKBTKEGFR | |
| SCHEMBL25603497 | 0.88 | JAK3 (0.62) | JAK3LCKBTKEGFR | |
| SCHEMBL21855187 | 0.88 | JAK3 (0.57) | JAK3LCKBTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081450-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |